RECOMBINANT INHIBITOR PROTEINS OF AN HK14 PROTEASE AND USE THEREOF

摘要

The present invention relates to a recombinant inhibitor protein of an hK14 protease comprising a Reactive Serpin Loop of a serpin sequence which is modified by at least one substrate active site sequence specific for said hK14 protease. Other objects of the invention are to provide a purified and isolated nucleic acid sequence encoding the recombinant inhibitor protein of said hKl 4 protease, an expression vector comprising said purified and isolated nucleic acid sequence, a eukaryotic or prokaryotic host cell transformed with this expression vector and a method of producing a recombinant inhibitor protein of an hK14 protease.