MONOPHOSPHORYLLIPID-A-DERIVATE UND VERFAHREN ZU DEREN HERSTELLUNG

摘要

Novel derivatives of monophosphoryl lipid A and a process for their preparation are provided. The derivatives contain one or more free groups, such as an amine, on a side chain attached to the primary hydroxyl groups of the monophosphoryl lipid A nucleus and an acylated hydroxy group. The derivatives provide a convenient method for coupling the lipid A through coupling agents to various biologically active materials and substrates, in order to utilise the immunostimulant properties of lipid A.