发明名称 |
ESTERS OF TRI- AND TETRAPEPTIDES, INHIBITORS OF GASTRIC SECRETION, PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
<p>The invention relates to the peptides of the formula: <IMAGE> (I) in which: R represents hydrogen or a protecting group for the terminal amine group, such as t-butoxycarbonyl (Boc), benzyloxycarbonyl (Z) or lower alkanoyl; X1 represents either beta-Ala or a direct bond between R and the terminal amine group of the amino acid TRP; TRP denotes either the L isomer or the D isomer of tryptophan; X2 represents L-leucine, L-methionine or L-norleucine; and Y denotes hydrogen, a halogen atom (preferably fluorine or chlorine), a trifluoromethyl group, a cyano group or a nitro group. These peptides inhibit gastric secretion.</p> |
申请公布号 |
EP0187095(B1) |
申请公布日期 |
1989.05.03 |
申请号 |
EP19850402528 |
申请日期 |
1985.12.18 |
申请人 |
SANOFI, SOCIETE ANONYME;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
MARTINEZ, JEAN;BALI, JEAN PIERRE;MAGOUS, RICHARD;CASTRO, BERTRAND;DEMARNE, HENRI |
分类号 |
C07K5/08;A61K38/00;A61P1/00;C07K5/097;C07K5/10;C07K14/575 |
主分类号 |
C07K5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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