Process for the preparation of 6,11-dihydro-5H-pyrido(2,3-b)(1,5)benzodiazepin-5-one.

摘要

The present invention is concerned with a process for the preparation of 6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one by the condensation of 2-chloronicotinic acid and o-phenylenediamine in a cyclic organic solvent at an elevated temperature, in which the reaction of condensation is carried out at a temperature of 100 to 190 DEG C in a cycloalkanol or a mixture of cycloalkanols as [a] cyclic organic solvent(s). The end product is in pure state and it may be utilized as such.