17 Beta-substituted-4-aza-5 alpha-androstenones and their use as 5 alpha-reductase inhibitors.

摘要

Compounds of formula: <CHEM> in which R is hydrogen, methyl or ethyl; R<2> is a branched alkyl radical having up to 12 carbon atoms; R min is hydrogen or methyl; R sec is hydrogen, alpha -methyl or beta -methyl, and R''' is hydrogen, alpha -methyl or beta -methyl, and pharmaceutical formulations containing the above compounds are active as testosterone 5 alpha -reductase inhibitors and thus are useful topically for treatment of acne, seborrhoea and female hirsutism, and systemically in the treatment of benign prostatic hypertrophy.