Cerebral function enhancing diazinylpiperidine derivatives

摘要

A series of diazinylpiperidine compounds of Formula I <IMAGE> I wherein X is an ethylene chain or a 1,2-benzo ring; Y is carbonyl or methylene; R1 is hydrogen or lower alkyl; and Z is an R2, R3-disubstituted diazinyl ring selected from pyridazine, pyrimidine, and pyrazine ring systems. Pharmacologic and neuroanatomical testing demonstrates that compounds of the series act to enhance cerebral function in mammals, particularly when there is a deficit in normal cerebral functioning. Specific pharmacologic test results indicate that compounds of Formula I possess cognition and memory enhancing activity.