| 摘要 |
<p>NEW MATERIAL:A compound expressed by the formula [R1 are residue of nucleic acid bases which may have a protecting group, halogen or formula OX (X is H, protecting group or alkyl); R<2> is protecting group of H or hydroxyl group]. EXAMPLE:2',3'-Deoxy-2'-fluorouridine. USE:An antiulcer agent or antiviral agent. PREPARATION:For example, 5'-O-tert.-butyldimethylsilyl-2'-deoxy-2'-fluorouridine dissolved in methylene chloride, etc., is reacted with 4-dimethylaminopyridine and phenylchlorothionocarbonate added to the above-mentioned solution to afford 5'-O-tert.-butyldimethylsilyl-2',3'-dideoxy-2'-fluorouridine, which is then reacted with tetrabutylammonium added to the above-mentioned fluorouridine derivative and the resultant reaction product is purified with a column chromatography to provide the compound expressed by the formula.</p> |
