| 摘要 |
An isoxazol derivative, or its pharmacologically acceptable salt, having an excellent P38MAP kinase inhibiting potency, the pyrimidinylisoxazol derivative represented by the formula: wherein R1 is a hydrogen atom, lower alkyl, amino, halogen atom, lower alkoxy, etc.; R2 is a substituted or unsubstituted aryl, etc.; R3 is a hydrogen atom or lower alkyl; R4 is a substituted or unsubstituted phenyl, etc.; and Y is-CH2-,-CO-,-CH(CH 3)-,-O-,-NH-, etc.
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