PROCESS FOR PREPARING CEPHALOSPORIN DERIVATIVES

摘要

Title (I)[R1=2-(2-aminothiazol-4-yl)-2-syn-methoxyiminoacetyl, 2-(2- aminothiazol-4-yl)-2-syn-(2-carboxypropyl-2-oxyimino) acetyl, or D-(- )- α-(4-hydroxy-6-methylpyridine-3-carboxyimino)-α-(4-hydroxyphenyl)- acetyl; R2=acetoxymethyl, [(2,5-dihydro-6hydroxy-2-methyl-5-oxo- 1,2,4-triazin)-3-yl thiomethyl, (1methylpyrrolidineo)methyl, (1- pyridinium)methyl or [(1-methyl-1Htetrazole)-5-yl thiomethyl; M=hydrogen or potassium have superior pharmaceutical effects. A method for preparing title (I) comprises (a) reacting organic acid with mixture (II), and (b) reacting active ester made by step (a) with mixture (III).