PROCESS FOR PRODUCING NEW AMIDES OF BUTENIC ACID AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE COMPONENTS

摘要

Compounds of the general formula (I), wherein R is hydrogen, halogen, C1-4alkyl, C1-4alkoxy or C1-4acylamino group; R1 is hydrogen or a carboxyl-protective group; and R2 represents a -(CH2)n-CO2R5 group, wherein n is 1, 2, 3 or 4; and R5 is hydrogen or a carboxyl-protective group; or R2 is a -(CH2)n-NH2 group, wherein n is 1, 2, 3 or 4 in the E and/or Z configuration, as well as their salts, show a cytoprotective effect and promote the healing of stomach ulcers. Their toxicity is low.