Process for the preparation of t-PA

摘要

Method for increasing the production of t-PA in cultures of t-PA-producing cells, in which a substance which induces the production of t-PA is added to the cell culture, characterised in that the t-PA-inducing substance used is thioglycolic acid, thiodiglycolic acid, L-cysteine, glutathione, butyrylcholine bromide, butyrylcholine chloride, nonactin acid, furan fatty acid, ascorbic acid, aphidicolin, 6-hydroxy-4,6-dimethyl-3-hepten-2-one, fusaric acid, mevalonic acid, trans-anhydromevalonic acid, anhydromevalonic acid lactone, cis-anhydromevalonic acid lactone, D- alpha -hydroxy-substituted (C3 or C4)aliphatic mono- or dicarboxylic acid or salts thereof.