发明名称 |
TRIPLY CLONED HEPATITIS A LIVE ATTENUATED VIRUS |
摘要 |
<p>Human hepatitis A virus (HAV) can be purified by a process in which master seed lots of HM-175 strain of hepatitis A virus are prepared from triply cloned virus by terminal dilution at passage level about 20 or preferably at least 20-30. The clones tested induced minimal or no hepatitis although significant antibody response was provoked in inoculated primates. A method of preparing the triply cloned inoculum is also described.</p> |
申请公布号 |
AU583306(B2) |
申请公布日期 |
1989.04.27 |
申请号 |
AU19850048620 |
申请日期 |
1985.09.18 |
申请人 |
UNITED STATES OF AMERICA, REPRESENTED BY THE DEPARTMENT OF COMM |
发明人 |
RICHARD J. DAEMER;STEPHEN M. FEINSTONE;IAN D. GUST;ROBERT H. PURCELL |
分类号 |
A61K39/00;A61K39/29;C12N7/00;C12N7/02;C12N7/08;(IPC1-7):A61K39/29 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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