发明名称 NUCLEOSIDE ANALOGUES
摘要 This invention discloses a group of compounds of formula (I) <CHEM> wherein R<1> is hydrogen, halo, C1-4 alkyl, C1-4 alkoxy COOR<4> (R<4> is H or C1-4 alkyl) or trifluoromethyl; R<2>, R<5> and R<6> are the same or different and can be hydrogen, hydroxy, OCOR<7> (wherein R<7> is hydrogen, C1-4 alkyl, phenyl optionally substituted) or halo; and R<3> is hydrogen, COR<4>, C3-6 cycloalkyl or C1-4 alkyl or alkenyl; R<2> may also be a phosphate group and pharmaceutically acceptable salts thereof which have been found to have analgesic activity. In addition, these compounds have antiinflammatory, antipyretic, antihypertensive and vasodilatory activity in varying degrees. Some of these compounds also have antiprotozoal and antiviral properties.
申请公布号 ZA8706673(B) 申请公布日期 1989.04.26
申请号 ZA19870006673 申请日期 1987.09.07
申请人 THE WELLCOME FOUNDATION LIMITED 发明人 THOMAS ANTHONY KRENITSKY;JANET LITSTER RIDEOUT;GEORGE WALTER KOSZALKA
分类号 C07H19/23;A61K31/70;A61K31/7042;A61K31/7052;A61P9/08;A61P9/12;A61P25/04;A61P29/00;A61P31/12;A61P33/02;C07H19/16 主分类号 C07H19/23
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