| 摘要 |
A process for preparing a hollow tube drug delivery system comprises : a. extruding a polymer solution or suspension through an annular orifice to provide a tubular membrane having a hollow core; b. simultaneously extruding a drug suspended in a polymer solution into the hollow core of the tubular membrane to provide a drug encapsulated tubular membrane system; c. passing the system into a non-solvent for the polymers having a density different from that of the system, to coagulate the polymers under conditions to minimize orientation in the tube polymer and to create pores in the tube polymer wall; d. removing residual solvent from the system; and e. collecting a drug encapsulated, porous polymeric hollow tube. The resulting system is used for coontrolled release of the encapsulated drug, and more particularly for release of the drug at a constant rate (zero order) for long periods of time. |
