| 发明名称 |
Mutated constitutively active nuclear orphan receptor |
| 摘要 |
Disclosed are constitutively active nuclear orphan receptors (CAR), which include one or more mutations which decrease the constitutive nature of CAR in vitro. The resulting non-constitutively active nuclear orphan receptors can be used to screen for agents that metabolize xenochemicals and/or steroids.
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| 申请公布号 |
US7365160(B2) |
申请公布日期 |
2008.04.29 |
| 申请号 |
US20040505183 |
申请日期 |
2004.08.18 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
NEGISHI MASAHIKO;UEDA AKIKO;PEDERSEN LARS C.;KAKIZAKI SATORU;SUEYOSHI TATSUYA |
| 分类号 |
C07K1/00;C07K14/705;C12N5/00;C12N15/12;C12P21/06 |
主分类号 |
C07K1/00 |
| 代理机构 |
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