DIFFICOL, INTERMEDIATE IN ANTIBIOTIC PREPARATION

摘要

TITLE OF THE INVENTION DIFFICOL, INTERMEDIATE IN ANTIBIOTIC PREPARATION The subject disclosure discloses a chemical intermediate in antibiotic synthesis of the structure: wherein R is H or OH and the asterisks indicate asymmetric carbon atoms. Compounds of this type may be obtained by fermentation with a strain of B. subtilis under aerobic conditions. Compounds of the - ii above structure are biologically inactive but are converted by phosphorylation of the hydroxyl group to produce compounds of the structure: II wherein R1 is H or OH, which are useful antibacterial substances having a broad spectrum of antibacterial activity.