| 摘要 |
16-KETO-17-SUBSTITUTED THIA-17-ALKYL (OR ALKENYL OR ALKYNYL )ANDROSTENES Antiinflammatory activity is exhibited by new steroids having the formula <IMG> and the 1,2-dehydro derivatives thereof, wherein R1 is alkyl, mono-, di- or trifluoroalkyl, R6 <IMG> , aryl or alkylthioalkyl, wherein R6 is alkyl or aryl and m is 1, 2, 3 or 4; R2 is <IMG> wherein R7, R8 and R9 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; R3 is carbonyl or .beta.-hydroxymethylene; R4 is hydrogen or halogen; R5 is hydrogen, methyl or fluorine; and n is 0, 1 or 2; with the proviso that if R1 is alkylthioalkyl, n is 0.
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