发明名称 |
Process for the production of 4-hydroxy-2-oxo-pyrrolidin-1-yl acetamide |
摘要 |
Process for the production of 4-hydroxy-2-oxo-pyrrolidin-1-yl acetamide. A 4-(C1-C2)-alkoxy-3-pyrrolin-2-on-1-yl-acetic acid (C1-C4)-alkyl ester of the formula: <IMAGE> wherein R1 is alkyl having 1 or 2 C atoms and R2 is alkyl having 1 to 4 C atoms, is reacted with either trichloromethylsilane in the presence of an alkali iodide or in an acid anhydrous medium to a 2,4-dioxo-pyrrolidin-1-yl-acetic acid (C1-C4)-alkyl ester. The latter is optionally isolated and then hydrogenated with sodium borohydride to a 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetic acid (C1-C4)-alkyl ester. Finally, the 4-hydroxy-2-oxo-pyrrolidin-1-yl-acetic acid (C1-C4)-alkyl ester is converted by amidation with ammonia to the desired end product.
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申请公布号 |
US4824966(A) |
申请公布日期 |
1989.04.25 |
申请号 |
US19880188702 |
申请日期 |
1988.05.04 |
申请人 |
LONZA LTD. |
发明人 |
MEUL, THOMAS;MCGARRITY, JOHN |
分类号 |
C07D207/38;(IPC1-7):C07D207/27 |
主分类号 |
C07D207/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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