| 摘要 |
<p>Disclosed is a compound represented by the general formula (I), a salt or N-oxide of the compound, a solvate of the compound, salt or N-oxide, or a prodrug of the compound, salt, N-oxide or solvate, which can bind specifically to CCR5 and therefore is useful for the prevention and/or treatment of a CCR5-associated disease, such as an inflammatory disease (e.g., asthma, nephritis, nephropathia, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis), an immune-mediated disease (e.g., autoimmune disease, rejection after organ transplantation, immunosuppression, psoriasis, multiple sclerosis), an infectious disease (e.g., infection with human immunodeficiency virus, acquired immunodeficiency syndrome), an allergic disease (e.g., atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis), suppression of ischemia-reperfusion injury, acute respiratory syndrome, shock associated with a bacterial infection, diabetes, cancer metastasis or the like. (I) wherein each symbol is as defined in the description.</p> |
