CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF ISCHEMIA

摘要

Chromen-4-one derivatives are provided to protect cells in the ischemic area by controlling calcium homeostasis and HSP(heat shock protein) expression, so that the compounds are useful for the treatment or prevention of ischemic diseases including angina pectoris, myocardial infarction, cerebral apoplexy and cerebral vascular dementia. Chromen-4-one derivatives represented by the formula(1) are useful for treatment or prevention of ischemic diseases, wherein X is single bond, O, S, S(O), SCH2, Se, NH, CH2, CH2CH2 or CH=CH; R1 is C1-C6 alkyl group; phenyl group optionally substituted by halogen atom, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkylcarbonate or amino C1-C6 alkylcarbonate; pyridine group; or piperidine group optionally substituted by C1-C6 alkyl or C1-C6 alkoxy group; R2 is hydrogen atom or C1-C6 alkyl group; R3 is hydrogen atom, hydroxyl, C1-C6 alkoxy group, or C1-C6 alkylcarbonate group; R4 is hydrogen atom, halogen atom, hydroxyl group, C1-C6 alkyl group or C1-C6 alkoxy group; R5 is halogen atom; C1-C6 alkyl group, C1-C6 alkylcarbonate group, C1-C6 alkylhydroxy C1-C6 alkanoate group; hydroxyl group; C1-C6 alkoxy group; hydroxyl C1-C6 alkoxy group; benzyl C1-C6 alkoxy group optionally substituted by halogen atom, C1-C6 alkyl or C1-C6 alkoxy group; phenyl C1-C6 alkoxy group optionally substituted by C1-C6 alkyl or C1-C6 alkoxy group; pyridinyl C1-C6 alkoxy group; oxypyridinyl C1-C6 alkoxy group; piperidinyl C1-C6 alkoxy group; or morpholinyl C1-C6 alkoxy group; and R6 is hydrogen atom, halogen atom, C1-C6 alkyl group or C2-C6 alkenyl group.