| 摘要 |
NEW MATERIAL:An azetidinone derivative shown by the formulaI(R<1> is H, lower alkyl; R<2> is lower alkyl, aralkyl, aryl; R<3> is H, OH-protecting group; Ar is aryl; n is 0-2). EXAMPLE:3S-(1R-Hydroxyethyl)-1-( 4-methoxyphenyl )-4R-( phenylsulfonyl )azetidine-2-one. USE:An intermediate for synthesizing a thienamycin type compound, an antibiotic having antimicrobial activity. PROCESS:For example, a compound shown by the formula II (n is 0 in the compound shown by the formulaI) is treated with an oxidizing agent (e.g., organic oxidizing agent, inorganic oxidizing agent, etc.) in a solvent at -80-100 deg.C for 30min-24hr, to give a compound shown by the formulaIwhere n is 1 or 2 in the formulaI. |
