PROSTAGLANDIN INTERMEDIATES, THEIR SYNTHESIS AND THEIR CONVERSION TO PROSTAGLANDINS

摘要

Prostaglandins such as 9-deoxo-9-methylene-16,16-dimethyl-PGE2, PGE2 and PGF2 alpha are prepared by a novel process, from D-glucose. The process involves a number of steps, including the preparation of novel intermediates including 2,3-disubstituted-4,5-tetrahydrofurandiols protected with the, for example, 2,2-propylidene radical.