| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R<1> and R<2> represent 1-8C alkyl or aryl or form a ring together with a carbon atom. to which they are bound; R<3> and R<4> represent H, 1-8C alkyl or aryl or form a ring together with a carbon atom. to which they are bound). EXAMPLE:(2-Amino-2-methyl-1-propanoxy)-borane. USE:Useful for reducing acetyl group at the 3-position of a 3-acetyl-2-azetidinone derivative to desired (R)-1-hydroxyethyl group in high selectivity. PREPARATION:A 2-aminoalcohol derivative expressed by formula II is reacted with a borane compound such as borane.tetrahydrofuran complex, etc., preferably in 1-3 molar equivalents. |
