| 摘要 |
NEW MATERIAL:A compound expressed by formula I (R is formula II-IV). EXAMPLE:A compound expressed by formula V. USE:An immunosuppressive agent and antiviral agent, capable of selectively acting only on cells, such as lymphocytes, in charge of immunity with the minimum side effects other than immunosuppressive action. PREPARATION:(A) Oxetanocin is reacted with (B) a culture of a microorganism, treated substance thereof or substance collected from animal tissues (e.g. homogenate of rat livers or enzyme purified and isolated therefrom), etc. Furthermore, e.g. Streptomyces.alboniger IFO 12738, is preferably used as the above- mentioned microorganism. |
