发明名称 METHOD FOR PRODUCING CRYSTALS OF DIAZABICYCLOOCTANE DERIVATIVE AND STABLE LYOPHILIZED PREPARATION
摘要 The purpose of the present invention is to provide a method with which it is possible to easily produce crystals of compound (I) on an industrial scale, and to provide a stable lyophilized composition of said compound (I). It was discovered that a lyophilized composition having exceptional storage stability and in which compound (I) is in crystalline form can be obtained by lyophilizing an aqueous solution that contains said compound (I) and an inorganic salt such as sodium chloride, and that crystals of said compound (I) can be obtained from said aqueous solution even without lyophilization.
申请公布号 WO2016088863(A1) 申请公布日期 2016.06.09
申请号 WO2015JP84094 申请日期 2015.12.04
申请人 MEIJI SEIKA PHARMA CO., LTD. 发明人 OGAWA, TAKAYA;YOKOYAMA, TAKUYA;FURUYAMA, SHUSUKE;ICHIKI, MASATO;FUSHIHARA, KENICHI
分类号 C07D471/08;A61K9/19;A61K31/439;A61K47/04;A61P43/00 主分类号 C07D471/08
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