| 摘要 |
Thienopyrimidine derivatives represented by general formula (I), wherein R1 and R2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a lower alkyl group, a cyclic alkyl group or a phenyl group, or R1 and R2 may be bound to each other to form an alkylene chain for forming a ring, R3 represents a lower alkyl group or a group of formula (II) (wherein R4 represents a lower alkyl group, a lower alkoxy group or a halogen atom, m represents 0, 1 or 2 and R5 represents a hydrogen atom or a halogen atom) or pharmaceutically acceptable salts thereof, a pharmacological composition containing the same as effective ingredient, and an aldose reductase inhibitor are disclosed. <H0> ABSTRACT OF THE DISCLOSURE </H0> The present invention provides thienopyrimidine derivatives of the formula (I) <CHEM> wherein R1 and R2 are the same or different and each represent hydrogen, halogen, lower alkyl, cycloalkyl or pheny, R1 and R2 taken together may form a ring of an alkylene chain, R3 represents lower alkyl or a group of the formula <CHEM> (in which R4 is lower alkyl, lower alkoxy or halogen, m is 0, 1 or 2, and R5 is hydrogen or halogen) and Z is oxygen or sulfur, or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as an active principle and aldose-reductase inhibitors. |
