| 主权项 |
1. A pupilometer, comprising:
a stimulus source; an imaging system comprising an imaging sensor that detects and monitors a pupillary response following delivery of a stimulus from the stimulus source; and a microprocessor coupled to the imaging system, wherein the microprocessor is configured to perform the steps of: (a) collecting a pupil data profile comprising pupil diameter measurements as a function of time; (b) smoothing the pupil data profile to remove physiological and instrumental noise, thereby resulting in a smoothed data profile; (c) determining time values associated with each of a plurality of pupil diameter values on the smoothed data profile; (d) determining whether the following conditions are met: (i) no more than two data points exist representing the same pupil diameter at separate points in time during a period of no more than about four seconds, (ii) a first phase of the pupilary reflex response exists, wherein said first phase is characterized by a period of non-constriction immediately subsequent to stimulating the pupil, said first phase having a duration of greater than about 100 msec and less than about 1000 msec, (iii) if two data points exist representing the same pupil diameter at two separate points in time, then the duration of time between said two separate points in time is greater than about 100 msec, and (iv) during the first phase of the pupilary reflex, the diameter of the pupil does not increase before it decreases; and (e) providing an output indicating that the pupil reflex does not resemble a canonical reflex if one or more of said conditions is not met. |
