发明名称 |
STABLE SULPHO-ADENOSYL-L-METHIONINE (SAME) SALTS, PARTICULARLY SUITABLE FOR PARENTERAL USE |
摘要 |
The present invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts particularly suitable for parenteral use, their production process, and pharmaceutical compositions containing them as active principles. Said salts correspond to the general formula: SAMe.n(CH2)m(SO3H)2(I) where n can vary from 1 to 2 and m can vary from 3 to 12. The process for producing said salts consists of the following stages: (a) enriching the starting yeast with SAMe; (b) lysing the cells and recovering a solution rich is SAMe (cell lysate); (c) prepurifying the cell lysate by ultrafiltration; (d) passing the prepurified lysate through a column of weak acid ion exchange resin and eluting with the required disulphonic acid; (e) passing the eluate of said column through a column of absorption resin and washing with the required disulphonic acid; (f) concentrating the eluate of the latter column by reverse osmosis; (g) drying the concentrated solution. |
申请公布号 |
DE3568581(D1) |
申请公布日期 |
1989.04.13 |
申请号 |
DE19853568581 |
申请日期 |
1985.04.25 |
申请人 |
BIORESEARCH S.P.A. |
发明人 |
GENNARI, FEDERICO |
分类号 |
C07H19/167;A61K9/08;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7076;C07H19/16;C12N1/06;C12P13/12;C12P19/40;C12R1/645;(IPC1-7):C07H19/16 |
主分类号 |
C07H19/167 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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