Anthracycline Antibiotics.

摘要

Disclosed are anthracycline antibiotics of a formula (I): <CHEM> in which R<1> and R<2> are hydroxyl groups, R<3> is ethyl group, R<4> is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or R<1> and R<2> are hydroxyl groups, R<3> is 1-hydroxyethyl group, R<4> is hydrogen atom and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or R<1>, R<2> and R<4> are hydroxyl groups, R<3> is ethyl group and X represents daunosamine-rhodenose, daunosamine-deoxyfucose, rhodosamine-rhodenose, N-monomethyldaunosamine-rhodenose or N-monomethyldaunosamine-deoxyfucose; or R<1> is methoxy group, R<2> is hydroxyl group, R<3> is ethyl group, R<4> is methoxycarbonyl group and X represents daunosamine-rhodenose or daunosamine-deoxyfucose; or R<1> and R<4> are hydroxy groups, R<2> is hydrogen atom, R<3> is ethyl group and X represents daunosamine-deoxyfucose, as well as pharmaceutically acceptable acid addition salts thereof. The antibiotics (I) have a carcinostatic activity and are useful as a carcinostatic.