Pyridine or pyridazine derivatives as cardio-protective agents and for the treatment of ischemic disease, and process for their preparation.

摘要

A pharmaceutical composition as a cardioprotective agent or as a therapeutic agent for ischemic disease comprising a compound of the formula: <CHEM> wherein R<1> is lower alkyl substituted with a heterocyclic group; carbamoyl substituted with heterocyclic(lower)alkyl or with lower alkylamino(lower)alkyl; N-containing heterocycliccarbonyl optionally substituted with lower alkyl; or ureido substituted with lower alkylamino(lower)alkyl; and R<2> is phenyl substituted with nitro, and X is =N- or = @@, in which R<3> is lower alkyl; or R<2> is lower alkyl, and X is = @@, in which R<3> is phenyl substituted with nitro; or its salt, as an active ingredient, in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient, and a process for the preparation of some of said compound or their salts