发明名称 |
2'-ALKYLIDENEPYRIMIDINE NUCLEOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE. |
摘要 |
<p>pyrimidine nucleosides of formula (I) and their salts are new: where R1 is amino or OH; R2 is H, halogen or lower alkyl; R3 is H or lower alkyl; R4 is H or a phosphate residue. Preferred are (I) where R3=H, and especially where R3=H and R2 is H, halogen or Me. Most preferred are (I) where R2=R3=H and R1 is amino; and where R1=OH, R2=Me and R3=H. (I) are prepd. from cpds. (II) where Z is a hydroxyl-protecting group; R5 is alkoxy, OH, amino or acylamino) by Wittig alkylidenation using for example Ph3P=CHR3, followed by removal of protecting groups and opt. phosphorylation.</p> |
申请公布号 |
EP0310673(A1) |
申请公布日期 |
1989.04.12 |
申请号 |
EP19880902560 |
申请日期 |
1988.03.17 |
申请人 |
YAMASA SHOYU KABUSHIKI KAISHA |
发明人 |
MATSUDA, AKIRA;UEDA, TORU;TAKENUKI, KENJI;MACHIDA, HARUHIKO |
分类号 |
C07H19/06 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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