| 发明名称 |
HIV-PROTEASEINHIBITORER, DER ER NYTTIGE TIL BEHANDLING AF AIDS |
| 摘要 |
<p>Compounds of the form A-G-B-B-J wherein A is an amine protecting group commonly employed in peptide synthesis, G a dipeptide isostere, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.</p> |
| 申请公布号 |
DK172389(D0) |
申请公布日期 |
1989.04.11 |
| 申请号 |
DK19890001723 |
申请日期 |
1989.04.11 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
SIGAL, IRVING S.;HUFF, JOEL R.;DARKE, PAUL L.;VACCA, JOSEPH P.;YOUNG, STEVEN D.;DESOLMS, S. JANE;THOMPSON, WAYNE J.;LYLE, TERRY A.;GRAHAM, SAMUEL L.;GHOSH, ARUN K. |
| 分类号 |
C12N9/99;A61K31/16;A61K31/195;A61K31/27;A61K31/275;A61K31/33;A61K31/35;A61K31/352;A61K31/415;A61K31/42;A61K31/421;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/4427;A61K31/47;A61K31/495;A61K31/496;A61K31/535;A61K31/5375;A61K31/5377;A61K31/66;A61K38/00;A61P31/12;A61P31/18;A61P37/04;A61P43/00;C07C229/12;C07C229/22;C07C229/26;C07C229/38;C07C229/46;C07C237/06;C07C237/08;C07C237/10;C07C237/12;C07C237/18;C07C237/20;C07C237/22;C07C271/22;C07C311/03;C07C311/05;C07C311/32;C07C311/46;C07C317/18;C07C317/48;C07C317/50;C07C323/59;C07C323/60;C07C323/61;C07C323/62;C07D209/10;C07D213/38;C07D213/40;C07D213/42;C07D215/14;C07D233/64;C07D235/24;C07D263/32;C07D295/12;C07D307/79;C07D311/68;C07D401/12;C07D457/02;C07D471/04;C07D521/00;C07F9/09;C07F9/30;C07F9/32;C07H13/02;C07H13/04;C07H15/04;C07K5/02;C07K5/06;C07K5/08;C07K14/81;(IPC1-7):C07C103/58;C07C149/43 |
主分类号 |
C12N9/99 |
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