发明名称 |
3-trifuoromethylsulfonyloxy-substituted 1-carbacephalosporins as intermediates for antibiotics |
摘要 |
7 beta -Acylamino-3-trifluoromethylsulfonyloxy-1-carba-3-cephem-4-carboxylic acid antibiotic compounds, esters and salts thereof, and the corresponding 7-amino and protected 7-amino 1-carbacephalosporins are provided. The 3-trifluoromethylsulfonyloxy-substituted 1-carbacephalosporins also are useful in a process for preparing 3-halo-1-carbacephalosporins which comprises reacting a 3-triflate ester with a lithium halide in an aprotic polar solvent.
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申请公布号 |
US4820816(A) |
申请公布日期 |
1989.04.11 |
申请号 |
US19880233088 |
申请日期 |
1988.08.17 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
EVANS, DAVID A.;SJOGREN, ERIC B. |
分类号 |
C07D463/00;(IPC1-7):C07D221/02 |
主分类号 |
C07D463/00 |
代理机构 |
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主权项 |
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地址 |
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