COMPLEXES OF TECHNETIUM-99M WITH PROPYLENE AMINE OXIMES

摘要

COMPLEXES OF TECHNETIUM-99m WITH PROPYLENE AMINE OXIMES A family of propylene amine oxime ligands has the formula 2 wherein preferably R1 is C1-C4 alkyl or phenyl and each of R, R2, R3 and R4 is H or C1-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and mesostereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R1=R2=CH3, R3=RI=H) show good retention in the brain.