发明名称 |
Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels |
摘要 |
Lesions in genetic sequences, for example, the sickle cell anemia mutation in the beta globin gene, are detected by means of interactive labels in a nucleic acid hybridization assay. A signal is generated only if the labels are in physical proximity which is made dependent on whether a predetermined normal or abnormal sequence is present by exposure to appropriate conditions such as restriction enzyme digestion or stringent hybridization.
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申请公布号 |
US4820630(A) |
申请公布日期 |
1989.04.11 |
申请号 |
US19840674190 |
申请日期 |
1984.11.23 |
申请人 |
DIGENE DIAGNOSTICS, INCORPORATED |
发明人 |
TAUB, FLOYD |
分类号 |
G01N33/50;C12N15/09;C12Q1/68;G01N33/58;H01R13/68;H01R13/74;(IPC1-7):C12Q1/68;C12Q1/70;C12Q1/28;C12Q1/32 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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