| 摘要 |
Disclosed is a process for preparing 3-substituted-thio-6-(1'-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2 -ene-2-carboxylic acids (I) <IMAGE> +TR <IMAGE> wherein X is a leaving group such as chloro, bromo, tosyl, mesyl or the like; and R8 is, inter alia, selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. The compounds I as well as their pharmaceutically acceptable O- and carboxyl derivatives are useful as antibiotics.
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