发明名称 |
Imidazoline derivative and method of treating depression therewith |
摘要 |
2-[2-(1,4-Benzodioxanyl)]-2-imidazoline or a non-toxic salt thereof, substantially free of 2-[2-(2-methyl-1,3-benzodioxyl)]- 2-imidazoline or a non-toxic salt thereof. 2-[2-(1,4-Benzodioxanyl)]-2-imidazoline or a non-toxic salt thereof characterised in that the nuclear magnetic resonance spectrum of the compound in a protonated form exhibits multiplets in the region of tau 4.4 and tau 5.4. Process for the preparation of 2-[2-(1,4-benzodioxanyl)]-2-imidazoline, pharmaceutical compositions thereof or of its salts, and their use as presynaptic alpha 2-adrenoreceptor antagonists.
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申请公布号 |
US4818764(A) |
申请公布日期 |
1989.04.04 |
申请号 |
US19810230195 |
申请日期 |
1981.02.02 |
申请人 |
RECKITT & COLMAN PRODUCTS LIMITED |
发明人 |
CHAPLEO, CHRISTOPHER;MYERS, PETER L. |
分类号 |
C07D405/04;A61K31/415;A61K31/4178;A61P3/08;A61P7/10;A61P9/06;A61P9/12;A61P25/00;A61P25/02;A61P25/04;A61P25/24;A61P25/26;C07D319/20;C07D407/06;(IPC1-7):A61K31/415;C07D403/00 |
主分类号 |
C07D405/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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