RADIOACTIVE DIAGNOSTIC AGENT, AND NON-RADIOACTIVE CARRIERS THEREFOR

摘要

: The invention provides a radioactive diagnostic agent which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound via a methyleneimine linkage (-CH=N-) or a methyleneamine linkage (-CH2NH-) formed by the condensation between a formyl group in the polyformyl compound and the amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing physiologically active substance bonded to the polyformyl compound via a methyleneimine linkage or a methyleneamine linkage formed by the condensation between a formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction, and (4) at least two radioactive metallic elements of which each is bonded to the chelating compound through a chelating bond. The diagnostic agent can be used for non-invading nuclear medical diagnosis.