发明名称 Complexes of Technetium 99m with propylene amine oximes
摘要 Novel propylene amine oxime ligands have the formula <IMAGE> where each of R1, R2, R3, R4, R5, R6, R7 or R8 may be hydrogen, hydrocarbon, carboxyl, amine, amide or nitrile, provided that, if R1 is the same as R9 and R2 is the same as R7, then R8 is not H. These unsymmetrical ligands form complexes with Technetium-99m which are capable, on injection into mammals, of crossing the blood-brain barrier and of being retained in the brain for a time to permit diagnosis.
申请公布号 US4818813(A) 申请公布日期 1989.04.04
申请号 US19870122507 申请日期 1987.11.18
申请人 AMERSHAM INTERNATIONAL PLC. 发明人 NOWOTNIK, DAVID P.;CANNING, LEWIS R.
分类号 A61K51/00;A61P43/00;C07C67/00;C07C239/00;C07C251/38;C07C251/40;C07C251/70;C07F13/00;(IPC1-7):A61K49/02;C07C131/00;C07D295/12 主分类号 A61K51/00
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