BIOLOGICAL MATERIALS, PROCESSES FOR PRODUCING BIOLOGICAL MATERIALS AND FOR USING SUCH MATERIALS IN THERAPY

摘要

This invention relates to interleukin 1 inhibitors (IL-1 INHs) that selectively inhibit interleukin 1 activity. The invention also relates to processes for purifying such IL-1 INHs from urine and for producing such IL-1 INHs by hosts transformed with recombinant DNA molecules comprising DNA sequences encoding the inhibitors, and to methods of treatment and compositions characterized by such IL-1 INHs. These methods and agents are useful in immunosuppressive and anti-inflammatory applications and therapies.