| 摘要 |
PCT No. PCT/GB84/00239 Sec. 371 Date Mar. 18, 1985 Sec. 102(e) Date Mar. 18, 1985 PCT Filed Jul. 4, 1984 PCT Pub. No. WO85/00521 PCT Pub. Date Feb. 14, 1985.Known disadvantages of protein Ca are overcome or reduced by acylating the protein to form a derivative which will gradually hydrolyse in vivo to regenerate the active enzyme. The enzyme derivative comprises protein Ca in which the active site essential for anti-coagulant activity is blocked by an acyl group removable in vivo by enzymatic hydrolysis to provide a sustained and controlled release of protein Ca, preferred acyl groups being optionally substituted benzoyl or acryloyl groups. |
