| 发明名称 |
ANTITUMOR AGENT OBTAINED BY MICROBIAL STEREOSELECTIVE REDUCTION OF 4'-DEOXY-4'-IODODOXORUBICIN |
| 摘要 |
4'-iododoxrubicin of formula (I) and its salts are new. (I) is prepd. by culturing Streptomyces peucetius strain M87 F.I. (DSM2444) in the presence of (II) and recovering (I) as such or as a salt. The strain M87 F.I. is obtd. by mutating S.peucetius subsp. aureus ATCC 31428 using nitrosoguanidine. |
| 申请公布号 |
ZA8804653(B) |
申请公布日期 |
1989.03.29 |
| 申请号 |
ZA19880004653 |
申请日期 |
1988.06.29 |
| 申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
GIUSEPPE CASSINELLI;TERESA BORDONI;SERGIO MERLI;GIOVANNI RIVOLA |
| 分类号 |
C12P19/56;A61K;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;C07G;C07H15/252;C12P29/00;C12R1/465 |
主分类号 |
C12P19/56 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
