发明名称 |
Methods for inducing general and localized bone apposition in-vivo |
摘要 |
The present invention provides unique methodologies for inducing new bone apposition in-vivo generally or at a localized site and for therapeutically treating a subject afflicted with a pathological disorder of bone which is characterized by a deficiency of calcium ions in the bone matrix. The methodology for treating generalized defective skeletile mineralization comprises administering sufficient quantities of alpha 2HS-glycoprotein to the subject such that the concentration of this naturally occurring plasma protein is not substantially less than about 600 micrograms per milliliter of serum in-vivo. Alternatively, the method for treatment of localized defective skeletile mineralization comprises administration of a therapeutic admixture containing about 300 mircograms of alpha 2HS-glycoprotein per gram of filler material to the site of skeletal defect.
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申请公布号 |
US4816437(A) |
申请公布日期 |
1989.03.28 |
申请号 |
US19870056023 |
申请日期 |
1987.06.01 |
申请人 |
TRUSTEES OF BOSTON UNIVERSITY |
发明人 |
NIMBERG, RICHARD B.;COLCLASURE, CRAIG;LLOYD, WELDON S. |
分类号 |
A61K38/00;C07K14/47;(IPC1-7):A61K37/02 |
主分类号 |
A61K38/00 |
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