| 摘要 |
Delta-opioid receptor antagonists are disclosed of the formula: <IMAGE> OR <IMAGE> wherein R1 is (C1-C5)alkyl, C3-C6(cycloalkyl)alkyl, C5-C7(cycloalkenyl)alkyl, aryl, aralkyl, trans-(C4-C5)alkenyl, allyl or furan-2-ylalkyl, R2 is H, OH or O2CR, wherein R is (C1-C5)alkyl; R3 is H, (C1-C5)alkyl or RCO; X is O, S or NY, wherein Y is H or (C1-C5)alkyl; M is N or CH; and R4 and R5 are individually H, F, Cl, Br, NO2, NH2, (C1-C5)alkyl or (C1-C5)alkoxy or R4 and R5 together are benzo; and the pharmaceutically acceptable salts thereof.
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