Radioprotective agents having an amino-thioalkyl structure

摘要

A pharmaceutical composition effective in the protection of normal tissues against radiation induced damage comprising administration a compound of the formula R1-CO-NR3-/A/-S-R2 in which R1 is a radical corresponding to an amino acid R1-COOH, /A/ is a C2 or C3 alkylene radical which can be substituted with a C1 to C3 alkyl radical, or with a hydroxy or hydroxycarbonyl radical or a -COR radical where R is an amino or -NH-CH2-CO2H radical, R2 is an acyl radical which protects the thiol group and which liberates the thiol group in vivo, R3 is a hydrogen, and also the salts of this compound with pharmaceutically acceptable acids.