| 摘要 |
4H-Quinolixin-4-onecarboxylic acids and derivs. of formula (I) and their salts are new. In (I), R1 = COOH, opt. substd. CONH2, CN, CSNH2 or tetrazolyl; R7 = H or aryl; R2 = H, OH, 1-6C alkyl or 1-6C alkoxy; R3 = H, OH, 1-6C alkyl, 1-6C alkoxy, opt. protected COOH, 2-6C alkenyloxy, opt. substd. aryl, arylthio, aroyl, aryl-(1-6C)alkyl, arenesulphonyl, arylamino opt. monosubstd. or aryloxy; or R2 + R3 = (CH2)3, CH=CH or CH=CH-CH=CH at any ring positions. Specifically claimed are N-(5-(1H-Tetrazolyl))-4H-quinol-izin-4-one-3-carboxamide (Ia) and the corresp. 1-Ph, 1-PhO and 1-PhCO cpds. and their Na salts, are specifically claimed. |
