| 摘要 |
NEW MATERIAL:The compound of formula I [J is phenylpyridyl, pyrazyl, indanyl, indanonyl, univalent group derived from cyclic amide or alkyl; B is group of formula II-IV (n is 0-10; R<2> is H or methyl; R<3> is H, alkyl, acylphenyl, etc.; R<4> is H, alkyl or phenyl), etc.; T is N or C; Q is T or N O; K is H, phenyl, arylalkyl, alkyl, pyridylmethyl, etc.; q is 1-3] and its salt. EXAMPLE:1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl) methylpiperidine. USE:It has strong and highly selective anti-acetylcholine esterase activity and is useful as a preventive and remedy for senile dementia. PREPARATION:A compound of formula I wherein B is group of formula IV can be produced e.g., by reacting an acid halide of formula V (Hal is halogen) with a cyclic amine derivative of formula VI in the presence of a salt-removing agent. |
