| 发明名称 |
4'-DEMETHYL-4-EPIPODOPHYLLOTOXIN DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS |
| 摘要 |
The present invention relates to novel 4 min -demethyl-4-epipodophyllotoxin derivatives of formula
<CHEM>
wherein R1 is an alkyl group; X1 and X2 are each a hydroxyl group or an amino group substituted by one or two alkyls, provided that either one of X1 and X2 is an amino group substituted by one or two alkyls, and the other is a hydroxyl group
and a process for their preparation. The compounds exhibit excellent anti-tumor activities and high water-solubility and can, therefore, be used as medicaments. |
| 申请公布号 |
DE3662104(D1) |
申请公布日期 |
1989.03.23 |
| 申请号 |
DE19863662104 |
申请日期 |
1986.03.26 |
| 申请人 |
MICROBIAL CHEMISTRY RESEARCH FOUNDATION |
发明人 |
UMEZAWA, HAMAO, PROF.;TAKEUCHI, TOMIO;KONDO, SHINICHI;TANAKA, WATARU;TAKITA, TOMOHISA;NISHIMURA, YOSHIO;YOSHIKAWA, HIROSHI |
| 分类号 |
A61K31/70;A61K31/7042;A61K31/7048;A61P35/00;C07H17/04;(IPC1-7):C07H17/04 |
主分类号 |
A61K31/70 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
