REGULATION OF EXPRESSION OF GM-CSF GENE

摘要

A method for controlling the expression of granulocyte/macrophage colony stimulating factor (GM-CSF) in cells which express GM-CSF, or for controlling the expression of other haemopoietic cytokines which contain the Ck-1 or Ck-2 DNA sequences in cells where they are expressed, which comprises the step of regulation of the binding of nuclear protein(s) in said cells with Ck-1 and Ck-2 in the promoter region of the GM-CSF gene or the said haemopoietic cytokine genes. The step of regulation of the binding of the nuclear protein(s) with Ck-1 and Ck-2 sequences may consist of the induction or promotion of binding, or alternatively, it may consist of the prevention or inhibition of binding. By way of example, regulation of the binding of the nuclear protein(s) may be effected by the use of DNA of a sequence which will act as a competitive inhibitor in the binding of protein(s).