| 摘要 |
The title cpds. (I)[R=H, halog, alkoxy, CF3; R1=H, alkyl; R2=CH2Ph, (un)substd. Ph, 2-pyridyl, pyrimidyl, 2-quinolinyl, 3benzisothazoyl; x=0, bond; n=2-4 were prepd.. Thus, piperazine (II)(R3=H) was N- alkylated with Br(CH2)3Cl to give 66% (II)[R3= (CH2)3Cl , which was treated with N2H4 to give 92% (II)[R3= (CH2)3NHNH2 . The cyclocondensation of (II) with EtC(S)NHCO2Et gave 72% piperazinopropyltriazole (III)(R4=H), which was Nalkylated with PhOCH2CH2Br to give 53% (III)(R4=CH2CH2OPh)(IV). (IV) is an antidepressant with minimal potential for side effects such as sedation and blood pressure lowering.
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